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Phenethylamines are a class of organic compounds characterized by a phenethylamine core structure, which consists of a benzene ring attached to an amino group via an ethyl chain. They occur naturally in the body as trace amines and act as central nervous system stimulants, influencing neurotransmission by binding to trace amine-associated receptors. Phenethylamines include many psychotropic substances such as amphetamines, methamphetamines, and MDMA, and have applications or effects as stimulants, empathogens, psychedelics, anorectics, bronchodilators, decongestants, and antidepressants. They are also found in various foods and organisms and produced biosynthetically from the amino acid L-phenylalanine. The class contains many derivatives formed by substitution on the core structure, leading to varied pharmacological actions.
Common medical uses of phenethylamines include their application as central nervous system stimulants and treatments for various conditions. Specifically, phenethylamine derivatives are used in:
Treatment of attention deficit hyperactivity disorder (ADHD) (e.g., dextroamphetamine)
Management of narcolepsy
Obesity treatment and weight loss management (e.g., dexfenfluramine and chlorphentermine as appetite suppressants)
Asthma, bronchitis, and chronic obstructive pulmonary disease (COPD) treatment through beta-2 adrenergic receptor agonists (e.g., carmoterol)
Cardiac support in heart disease (e.g., dobutamine as a beta-1 agonist)
Relief of nasal congestion and cough (e.g., ephedrine and dl-methylephedrine)
Treatment of depression and mood disorders, sometimes as supplements alongside antidepressants for improved effects
Enhancing athletic performance and improving focus and attention in some cases
Phenethylamines also have investigational uses linked to their interaction with various receptors such as adenosine and serotonin receptors, which relate to inflammation, cardiovascular function, and psychiatric conditions (like migraine, anxiety, schizophrenia, and panic disorders).
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